Anthony Fyles

Research Synopsis

• Hypoxia in tumours: Clinical and experimental studies
• NCIC EN 7 Randomized Trial Concurrent Chemo-RT in Endo Ca
• TARGIT IORT Randomized Trial in Early Breast Cancer
• OCOG PETLACE PET Randomized Trial – Staging in Cervical Cancer

Recent Publications

Fyles A, Milosevic M, Pintilie M, Syed A, Levin W, Manchul L, Hill RP. Long-term Performance of IFP and Hypoxia as Prognostic Factors in Cervix Cancer. Radiotherapy and Oncology 80 (2):132-137, August 2006.

Bachtiary B, Boutros PC, Pintilie M, Shi W, Bastianutto C, Li J-H, Schwock J, Penn LZ, Jurisica I, Zhang Z, Fyles A, Liu F-F. Gene expression profiling in cervical cancer – Exploring intra-tumor heterogeneity. Clin Cancer Res 12(19):5632-5640, October, 2006

Lim K, Chan P, Dinniwell R, Fyles A, Haider M, Cho YB, Jaffray D, Manchul L, Levin W, Hill RP, Milosevic M. Cervical cancer regression measured using weekly magnetic resonance imaging during fractionated radiotherapy: radiobiologic modeling and correlation with tumor hypoxia. Int J Radiat Oncol Biol Phys.; 70(1): 126-33. Jan 2008.

Chan P, Dinniwell R, Haider, MA, Cho YB, Jaffray D, Lockwood G, Levin W, Manchul L. Fyles A., Milosevic M. Inter- and Intrafractional Tumor and Organ Movement in Patients with Cervical Cancer Undergoing Radiotherapy: A Cinematic-MRI Point-of-Interest Study. Int J Radiat Oncol Biol Phys 70(5) 1507-1515, April, 2008

Lim K, Kelly V, Stewart J, Xie J, Cho YB, Moseley J, Brock K, Fyles A, Lundin A, Rehbinder H, Milosevic M. Pelvic radiotherapy for cancer of the cervix: is what you plan actually what you deliver? Int J Radiat Oncol Biol Phys. 74(1):304-12, May 1, 2009

Lim K, Small W Jr., Portelance L, Creutzberg C, Jurgenliemk-Schulz IM, Mundt A, Mell LK, Mayr N, Viswanathan A, Jhingran A, Erickson B, De Los Santos J, Gaffney D, Yashar C, Beriwal S, Wolfson A, Taylor A, Bosch W, El Naqa I,Fyles A; Gyn IMRT Consortium. Consensus guidelines for delineation of clinical target volume for intensity-modulated pelvic radiotherapy for the definitive treatment of cervix cancer. Int. J. Radiat. Oncol. Biol. Phys. 79(2), 348-355, February 2011 PubMed PMID: 20472347

Appointments

Professor, Department of Radiation Oncology, University of Toronto
Professor, Department of Obstetrics and Gynecology, University of Toronto
Staff Physician, Princess Margaret Hospital/University Health Network
Associate Member, Institute of Medical Science, University of Toronto