Academic Rank

Professor

Professional Qualifications

BASc, Engineering and Management, University of Waterloo
MD, Queen’s University
FRCPC, Radiation Oncology

Appointments

Professor, Department of Radiation Oncology, University of Toronto

Associate Director, Radiation Medicine Program, Princess Margaret Hospital/University Health Network, Toronto

Gynecologic cancer site leader, Radiation Medicine Program, Princess Margaret Hospital/University Health Network, Toronto

Director of Research, Radiation Medicine Program, Princess Margaret Hospital/University Health Network, Toronto

Director, STTARR Core III, University Health Network, Toronto

The STTARR Research Program and the STTARR Innovation Centre at UHN, integrate molecular, cellular, animal and patient imaging with precision radiation research in a manner conducive to the rapid translation of novel treatment strategies from the laboratory to clinical evaluation.

Biomechanical Research Group, Department of Applied Mathematics, University of Waterloo

Chair, Canadian Partnership for Quality Radiotherapy (CPQR)

CPQR is an alliance among the national professional associations involved in the delivery of radiation treatment in Canada (Canadian Association of Radiation Oncology – CARO, Canadian Organization of Medical Physicists – COMP, Canadian Association of Medical Radiation Technologists – CAMRT), together with the Canadian Partnership Against Cancer – CPAC, for the purpose of assuring the availability of high-quality radiation treatment for all Canadians.

Academic & Clinical Interests

• Gynecologic tumors, particular cervix cancer
• Genitourinary tumors, particularly bladder, prostate, and kidney cancers

Current Research Projects

Tumor microenvironment in gynecologic tumors and prostate cancer

• Clinical-translational studies of hypoxia, interstitial fluid pressure (IFP) and tumor metabolism in cervix and prostate cancer. Approximately 600 patients have been accrued to prospective translational studies.
• Functional and metabolic imaging of human tumors using dynamic CT, dynamic MR and PET
• Bioluminescence imaging of metabolism in human tumors
• Pre-clinical and clinical-translational evaluation of the anti-angiogenic drug sorafenib in combination with radiotherapy. Phase I-II studies are currently accruing patients with cervix cancer or renal cell carcinoma. Both studies include extensive evaluation of imaging and tissue-based biomarkers prior to and during treatment.
• Mathematical modeling of vascularity, interstitial fluid dynamics and treatment response in tumors

Adaptive, image-guided radiotherapy for gynecologic tumors

• Assessment of cervix, uterine and normal tissue motion using 4D-MR imaging
• Evaluation of online daily imaging techniques for measuring target motion during radiotherapy
• Development of intensity modulated radiotherapy (IMRT) approaches for treating cervix cancer, including image-guided adaptive radiotherapy with interactive re-planning during fractionated treatment to compensate for changing tumor volume and position
• Development and implementation of MR-guided brachytherapy for cervix cancer, with treatment optimization in individual patients

Selected Publications

See current publications list at PubMed.

Lim K, Kelly V, Stewart J, Xie J, Cho Y-B, Moseley J, Fyles A, Lundin A, Rehbinder H, Milosevic M. Pelvic radiotherapy for cervix cancer: Is what you plan actually what you deliver? Int J Radiat Oncol Biol Phys, 74(1), 304-12, 2009.

Zwahlen D, Jezioranski J, Chan P, Haider M, Cho Y-B, Yeung I, Levin W, Manchul Fyles A, Milosevic M. Magnetic resonance image-guided intracavitary brachytherapy for cervix cancer. Int J Radiat Oncol Biol Phys, 74(4), 1157-64. 2009.

Dinniwell R, Chan P, Czarnota G, Haider M, Fyles A, Jaffray D, Milosevic M. Pelvic lymph node topography for radiotherapy treatment planning from contrast-enhanced MR imaging. Int J Radiat Oncol Biol Phys, 74(3), 844-51, 2009.

Stewart J, Lim K, Kelly V, Xie J, Brock K, Moseley J, Cho Y-B, Fyles A, Lundin A, Rehbinder H, Löf J, Jaffray D, Milosevic M. Automated weekly replanning for intensity-modulated radiotherapy of cervix cancer. Int J Radiat Oncol Biol Phys, 2009.

Chopra S, Milosevic M, Haider M, Bristow R, Menard C. Comparing oxygen-sensitive MRI (BOLD R2*) with oxygen electrode measurements: A pilot study in men with prostate cancer. Int J Radiat Biol, 85(9), 805-13, 2009.

Molavian H, Kohandel M, Milosevic M, Sivaloganathan S. Fingerprint of cell metabolism in the lack of correlation between the interstitial pH and pO2 in solid tumors. Cancer Res, 69(23), 9141-7, 2009.