Academic Rank

Professor

Professional Qualifications

MSc, University of Toronto
PhD, University of Toronto
MD, University of Toronto
FRCPC, Radiation Oncology

Appointments

Professor, Department of Radiation Oncology, University of Toronto
Professor, Department of Medical Biophysics, University of Toronto
Radiation Oncologist, Princess Margaret Hospital/University Health Network
Clinician-Scientist, Ontario Cancer Institute, Princess Margaret Hospital

Associate Member, Institute of Medical Sciences, University of Toronto

Academic & Clinical Interests

• Prostate Carcinogenesis and Radiobiology translational research: use of primary human prostate biopsies to predict radiation response and tumour progression
• Basic research in DNA damage signaling and repair: interest in ATM/p53 and HR/NHEJ pathways of signaling DNA damage in oxic and hypoxic tissues; use of confocal microscopy and biochemistry to track DNA repair complexes in situ

Current Research Projects

• Spatio-Temporal Targeting and Amplification of Radiation Response program (STTARR)
• Medical biophysics
• Laboratory

Selected Publications

See current publications list at PubMed.
Ishkanian AS , Mallof CS, Ho J, Meng A, Albert M, Syed A, van der Kwast T, Milosevic M, Yoshimoto M, Squire JA, Lam W and Bristow RG. High-Resolution Array CGH Identifies Novel Regions of Genomic Alteration in Intermediate-Risk Prostate Cancer. Prostate, 69(10): 1091-100, 2009. (IMPACT FACTOR 4.1)

Ali M, Kim H, Cleary S, Gallinger S, Cupples, C, Bristow R: Characterization of mutant MUTYH proteins associated with familial colorectal cancer, Gastroenterology, 135(2):499-507, August 2008. (IMPACT FACTOR 14)

Bristow R and Hill RP. Hypoxia, DNA-dsb Repair and Genetic Instability. Nature Reviews Cancer, 8(3): 180-192, 2008.

Chan N, Koritzinsky M, Zhao H, Bindra R, Glazer PM, Powell S, Belmaaza A, Wouters B, Bristow R. Chronic hypoxia decreases synthesis of homologous recombination prteins to offset chemoresistance and radioresistance. Cancer Research, 68(2):605-14, 2008.

Al Rashid ST, Dellaire G, Cuddihy A, Jalali F, Vaid M, Coackley C, Folkard M, Xu Y, Chen B, Chen D, Lilge L, Prise K, Bazett-Jones D and Bristow R. Evidence for the Direct Binding of Phosphorylated p53 to Sites of DNA Break In Vivo”. Cancer Research, 65(23):10810-10821, 2005.